Edward B. Skibo: search on Z-Library

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1

Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents

Islam, Imadul, Skibo, Edward B., Dorr, Robert T., Alberts, David S.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.10 MB

english, 1991

2

Pyrimidoquinazoline-Based Antitumor Agents. Design of Topoisomerase II to DNA Cross-linkers with Activity against Protein Kinases

Skibo, Edward B., Huang, Xiaofen, Martinez, Rogelio, Lemus, Robert H., Craigo, William A., Dorr, Robert T.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 301 KB

english, 2002

3

ChemInform Abstract: Design of Cancer-Specific Antitumor Agents Based on Aziridinylcyclopent[b]indoloquinones.

Chengguo Xing, Ping Wu, Edward B. Skibo, Robert T. Dorr

Journal:

Year:

2000

Language:

english

File:

PDF, 32 KB

english, 2000

4

ChemInform Abstract: Aziridinyl Quinone Antitumor Agents Based on Indoles and Cyclopent[b]indoles: Structure—Activity Relationships for Cytotoxicity and Antitumor Activity.

Edward B. Skibo, Chengguo Xing, Robert T. Dorr

Journal:

Year:

2002

File:

PDF, 28 KB

2002

5

ChemInform Abstract: Characterizing Quinone Methides by Spectral Global Fitting and 13C Labeling

Edward B. Skibo

Journal:

Year:

2010

File:

PDF, 15 KB

2010

6

Rational Design of Pyrrolo[1,2-a]benzimidazole-Based Antitumor Agents Targeting the DNA Major Groove

Xiaofen Huang, Ali Suleman, Edward B. Skibo

Journal:

Bioorganic Chemistry

Year:

2000

Language:

english

File:

PDF, 3.22 MB

english, 2000

7

Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products

Daniel V. LaBarbera, Edward B. Skibo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 352 KB

english, 2005

8

Rational design of purine nucleoside phosphorylase inhibitors: Design of 2-(2′-Haloethyl) and 2-ethenyl substituted quinazolinone alkylating agents.

Robert O. Dempcy, Edward B. Skibo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 668 KB

english, 1992

9

Design of quinolinedione-Based geldanamycin analogues

Robert Hargreaves, Cynthia L. David, Luke Whitesell, Edward B. Skibo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

10

Kinetic studies of 2-(2′-haloethyl) and 2-ethenyl substituted quinazolinone alkylating agents. Acid-catalyzed dehydrohalogenation and alkylation involving a quinazolinone prototropic tautomer

Robert O. Dempcy, Edward B. Skibo

Journal:

Bioorganic & Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 590 KB

english, 1993

11

Recognition and cleavage at the DNA major groove

Edward B. Skibo, Chenggou Xing, Thomas Groy

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 463 KB

english, 2001

12

Pyrrolo[1,2-a]benzimidazole-Based Quinones and Iminoquinones. The Role of the 3-Substituent on Cytotoxicity

Schulz, William G., Islam, Imadul, Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.31 MB

english, 1995

13

Triple molecular target approach to selective melanoma cytotoxicity

Skibo, Edward B., Jamil, Akmal, Austin, Brittany, Hansen, Douglas, Ghodousi, Armand

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 499 KB

english, 2010

14

Inosine monophosphate dehydrogenase from porcine (Sus scrofa domestica) thymus: Purification and properties

Michael E. Pugh, Edward B. Skibo

Journal:

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry

Year:

1993

Language:

english

File:

PDF, 587 KB

english, 1993

15

Studies of Pyrrolo[1,2- a ]benzimidazolequinone DT-Diaphorase Substrate Activity, Topoisomerase II Inhibition Activity, and DNA Reductive Alkylation

Skibo, Edward B., Gordon, Samantha, Bess, Laura, Boruah, Romesh, Heileman, Matthew J.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 661 KB

english, 1997

16

Quinone methide chemistry of prekinamycins: 13C- labeling, spectral global fitting and in vitro studies

Khdour, Omar, Skibo, Edward B.

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 490 KB

english, 2009

17

Chemistry of the sulfur-nitrogen bond. XI. Synthesis and thermal decomposition of N,N'-thiodiamines

Davis, Franklin A., Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1976

Language:

english

File:

PDF, 569 KB

english, 1976

18

Inhibitors of Topoisomerase II Based on the Benzodiimidazole and Dipyrroloimidazobenzimidazole Ring Systems: Controlling DT-Diaphorase Reductive Inactivation with Steric Bulk

Schulz, William G., Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 397 KB

english, 2000

19

Aziridinyl Quinone Antitumor Agents Based on Indoles and Cyclopent[ b ]indoles: Structure−Activity Relationships for Cytotoxicity and Antitumor Activity

Skibo, Edward B., Xing, Chengguo, Dorr, Robert T.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 424 KB

english, 2001

20

Design of Cancer-Specific Antitumor Agents Based on Aziridinylcyclopent[ b ]indoloquinones

Xing, Chengguo, Wu, Ping, Skibo, Edward B., Dorr, Robert T.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 347 KB

english, 2000

21

Discovery of Quinolinediones Exhibiting a Heat Shock Response and Angiogenesis Inhibition

Hargreaves, Robert H. J., David, Cynthia L., Whitesell, Luke J., LaBarbera, Daniel V., Jamil, Akmal, Chapuis, Jean C., Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.26 MB

english, 2008

22

Design of a Cyclopropyl Quinone Methide Reductive Alkylating Agent. 2

Khdour, Omar, Ouyang, Anlong, Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

2006

Language:

english

File:

PDF, 243 KB

english, 2006

23

Chemistry of the sulfur-nitrogen bond. VII. Rearrangement of sulfenimines (S-aryl thiooximes) to .beta.-keto sulfides. Attempted synthesis of benzo[b]thiophenes

Davis, Franklin A., Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1974

Language:

english

File:

PDF, 685 KB

english, 1974

24

Chemistry of Pyrrolo[1,2- a ]indole- and Pyrido[1,2- a ]indole-Based Quinone Methides. Mechanistic Explanations for Differences in Cytostatic/Cytotoxic Properties

Khdour, Omar, Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 520 KB

english, 2007

25

Synthesis and electrochemistry of pyrimidoquinazoline-5,10-diones. Design of hydrolytically stable high potential quinones and new reductive alkylation systems

Skibo, Edward B., Gilchrist, James H.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 1.34 MB

english, 1988

26

Electronic probes of the mechanism of substrate oxidation by buttermilk xanthine oxidase: role of the active-site nucleophile in oxidation

Skibo, Edward B., Gilchrist, James H., Lee, Chang Hee

Journal:

Year:

1987

Language:

english

File:

PDF, 726 KB

english, 1987

27

A mechanistic study of 2-vinylbenzimidazole formation from 2-(2'-haloethyl)benzimidazoles. Synthesis of highly electron-rich vinylic compounds by general base and specific acid-general base catalysis

Boruah, Romesh C., Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 871 KB

english, 1993

28

A Comprehensive Study of the Active Site Residues of DT-Diaphorase: Rational Design of Benzimidazolediones as DT-Diaphorase Substrates †

Suleman, Ali, Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 341 KB

english, 2002

29

High- and low-potential flavin mimics (based on the pyrimidino[5,4-g]pteridine and imidazo[4,5-g]pteridine system). 1. General chemistry

Skibo, Edward B., Bruice, Thomas C.

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 1.37 MB

english, 1983

30

Synthesis of fused [1,2,6]thiadiazine 1,1-dioxides as potential transition-state analog inhibitors of xanthine oxidase and guanase

Meyer, Rich B., Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

1979

Language:

english

File:

PDF, 696 KB

english, 1979

31

The Synthesis of Vinylogous Amidine Heterocycles

LaBarbera, Daniel V., Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 1.13 MB

english, 2013

32

Synthesis and physical studies of azamitosene and iminoazamitosene reductive alkylating agents. Iminoquinone hydrolytic stability, syn/anti isomerization, and electrochemistry

Islam, Imadul, Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 1.49 MB

english, 1990

33

Solution Kinetics of CC-1065 A-Ring Opening: Substituent Effects and General Acid/Base Catalysis

LaBarbera, Daniel V., Skibo, Edward B.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

34

Chemistry of the sulfur-nitrogen bond. 12. Metal-assisted synthesis of sulfenamide derivatives from aliphatic and aromatic disulfides

Davis, Franklin A., Friedman, Arthur J., Kluger, Edward W., Skibo, Edward B., Fretz, E. Robert, Milicia, Anthony P., LeMasters, William C., Bentley, Michael D., Lacadie, John A., Douglass, Irwin B.

Journal:

Journal of Organic Chemistry

Year:

1977

Language:

english

File:

PDF, 713 KB

english, 1977

35

Noncompetitive and irreversible inhibition of xanthine oxidase by benzimidazole analogs acting at the functional flavin adenine dinucleotide cofactor

Skibo, Edward B.

Journal:

Year:

1986

Language:

english

File:

PDF, 750 KB

english, 1986

36

Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity

Skibo, Edward B., Schulz, William G.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.34 MB

english, 1993

37

Structure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison of benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogs

Skibo, Edward B., Islam, Imadul, Heileman, Matthew J., Schulz, William G.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.29 MB

english, 1994

38

Sigmatropic Reactions of the Aziridinyl Semiquinone Species. Why Aziridinyl Benzoquinones Are Metabolically More Stable than Aziridinyl Indoloquinones †

Xing, Chengguo, Skibo, Edward B.

Journal:

Year:

2000

Language:

english

File:

PDF, 164 KB

english, 2000

39

Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase

Dempcy, Robert O., Skibo, Edward B.

Journal:

Year:

1991

Language:

english

File:

PDF, 985 KB

english, 1991

40

The preparation and study of a low potential flavin analog

Skibo, Edward B., Bruice, Thomas C.

Journal:

Journal of the American Chemical Society

Year:

1982

Language:

english

File:

PDF, 387 KB

english, 1982

41

High- and low-potential flavin mimics. 2. 3,7,10-Trimethyl-(1H,3H,5H,7H,9H,10H)-pyrimido[5,4-g]pteridine-2,4,6,8-tetrone dianion reduction of carbonyl, nicotinamides, and alkyl disulfide functional groups

Skibo, Edward B., Bruice, Thomas C.

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 1.46 MB

english, 1983

42

Active-site-directed reductive alkylation of xanthine oxidase by imidazo[4,5-g]quinazoline-4,9-diones functionalized with a leaving group

Lee, Chang Hee, Skibo, Edward B.

Journal:

Year:

1987

Language:

english

File:

PDF, 983 KB

english, 1987

43

Studies of extended quinone methides. The hydrolysis mechanism of 1-methyl-2-(bromomethyl)-4,7-dihydroxybenzimidazole

Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 852 KB

english, 1986

44

A Comparison of the Cytotoxic and Physical Properties of Aziridinyl Quinone Derivatives Based on the Pyrrolo[1,2-a]benzimidazole and Pyrrolo[1,2-a]indole Ring Systems

Boruah, Romesh C., Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.58 MB

english, 1994

45

Synthesis, electrochemistry, and xanthine oxidase substrate reactivity of imidazo[4,5-g]quinazoline-4,9-diones. Studies directed toward the design of purine-like reductive alkylators

Lee, Chang Hee, Gilchrist, James H., Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 1.25 MB

english, 1986

46

Synthesis and Biological Evaluation of Imidazoquinoxalinones, Imidazole Analogues of Pyrroloiminoquinone Marine Natural Products

Hoang, Hung, LaBarbera, Daniel V., Mohammed, Kaleem A., Ireland, Chris M., Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 309 KB

english, 2007

47

Formation and fate of benzimidazole-based quinone methides. Influence of pH on quinone methide fate

Skibo, Edward B.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 607 KB

english, 1992

48

Design of Highly Active Analogues of the Pyrrolo[1,2- a ]benzimidazole Antitumor Agents

Craigo, William A., LeSueur, Benjamin W., Skibo, Edward B.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 474 KB

english, 1999

49

Pyrrolobenzimidazoles in cancer treatment

Skibo, Edward B

Journal:

Expert Opinion on Therapeutic Patents

Year:

1998

Language:

english

File:

PDF, 388 KB

english, 1998

50

Facile oxidation of methoxide to formaldehyde by a heterocyclic quinone

Skibo, Edward B., Lee, Chang Hee

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 402 KB

english, 1985

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